Terreic acid is a metabolite that displays antibiotic properties. It has been found to covalently inhibit UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA), a bacterial cell wall biosynthetic enzyme. It has also been found to inhibit the catalytic activity of Bruton’s tyrosine kinase (BTK) and the interaction of BTK with protein kinase C beta type (PKCĪ²II) without affecting the activity of PKC. Terreic acid is useful to study BTK’s role in cellular signaling.
Biological Activity
Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.
More about: Terreic acid sale
Read more: Probiotics
No comments:
Post a Comment