CAS Registry Number: 59626-33-4
Formula: C6H4Br3NO2S
Molecular Weight: 393.88
Appearance White crystal
Purity (%) 99 min.
Loss on drying (%) 0.5 max.
Melting point (ºC) 159 - 162
Sulfapyridine, aboriginal UK spelling sulphapyridine, is a sulfonamide antibacterial. At one time it was frequently referred to as M&B.
Sulfapyridine is not assigned for analysis in bodies any more. However, it may be acclimated to amusement Linear IgA Disease. It is a acceptable antibacterial drug, but its baptize solubility is actual pH dependent. Thus there is a accident of condensate aural the float or urethra, which could advance to affliction or blockage.
Discovered by May & Baker Ltd and logged in their Test Book on 2 November 1937 beneath Code No M&B693. Successfully acclimated to amusement Winston Churchill's bacterial pneumonia in 1942. In a consecutive radio advertisement he said "This admirable M&B from which I did not ache any inconvenience, was acclimated at the ancient moment and, afterwards a week's fever, the intruders were repulsed." In 1944 M&B693 aswell adored Nero, the Royal Circus lion, from pneumonia.
The biologic sulfasalazine is structurally one atom of mesalamine affiliated to one atom of Sulfapyridine with an azo bond.
A sulfonyl accumulation can accredit either to a anatomic accumulation begin primarily in sulfones or to a substituent acquired from a sulfonic acerbic by the abatement of the hydroxyl accumulation analogously to acyl groups. Sulfonyl groups can be accounting as accepting the accepted blueprint R-S(=O)2-R', area there are two bifold bonds amid the sulfur and oxygen.
Sulfonyl groups can be bargain to the hydrocarbon with lithium aluminium hydride (LiAlH4).
In asleep chemistry, if the accumulation -S(=O)2- is not affiliated to any carbon atoms, it is referred to as sulfuryl.
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Read more: Pyridine synthesis
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