Methanesulfonamide
Molecular Formula CH5NO2S
Molecular Weight 95.12
CAS Registry Number 3144-09-0
Melting point 88-92 ºC
Methanesulfonamide derivatives of the formula, wherein R1 is hydrogen or a halogen atom, R2 and R3 are the aforementioned or altered and are anniversary hydrogen or a beeline or angled alkyl accepting 1 to 3 carbon atoms, and one of X and Y is a carbon atom and addition is a nitrogen atom, provided that the group: --CH2 SO2 NR2 R3 is affirmed to the carbon atom of either of X and Y,and an acrid metal alkali thereof, and a action for the alertness of said methane-sulfonamide derivatives. Said compounds accept an accomplished anticonvulsant action and are advantageous as anticonvulsants for authoritative amusement and seizures in patients with epilepsy.
A convenient, general, and high yielding Pd-catalyzed cross-coupling of methanesulfonamide with aryl bromides and chlorides is reported. The use of this method eliminates concern over genotoxic impurities that can arise when an aniline is reacted with methanesulfonyl chloride. The application of this method to the synthesis of dofetilide is also reported.
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