Bacitracin appears as a white or almost white powder, hygroscopic
Bacitracin is a mixture of related cyclic polypeptides created from organisms of the licheniformis group of Bacillus subtilis var Tracy, isolation of which was first reported in 1945.
As a toxic and difficult-to-use antibiotic, bacitracin does not cultivate fountainhead orally. Nonetheless, it is very effective topically, and embodies a more common ingredient of eye and skin antibiotic preparations. Its action is on Gram-positive cell walls. It give notice do inter-group communication dermatitis and cross-reacts with allergic sensitivity to sulfa-drugs. A non-ointment form of opthalmic solution is also available for eye infections.
Although allergic cross reaction with sulfa drugs has been occasionally reported, bacitracin-containing topical preparations remain a possible alternative to silver sulfadiazine (Silvadene) for burn patients with a sulfa allergy.
Bacitracin can also be bought in pure form for those with allergies to the polymyxin B and neomycin components of the combination product.
As bacitracin zinc salt, in combination with other topical antibiotics (usually polymyxin B and neomycin) as an ointment ("triple antibiotic ointment," with a common brand name Neosporin), it is used for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections.
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