Eflornithine HCl, 13.9% cream (VaniqaTM) is a novel treatment for the management of unwanted facial hair in women. It is a white or almost white crystalline powder. This paper reports the results of four modified open-label, within-subject vehicle-controlled studies evaluating the dermal safety of this topical treatment. In a three-week cumulative irritation study (30 subjects), the mean irritation score for sites treated with eflornithine HCl 13.9% cream was 1.33, compared with 0.76 at vehicle-treated sites and 3.09 at positive-control (sodium lauryl sulphate-treated) sites (p < 0.001 between all three groups). It can be made cream of Eflornithine HCL(Vaniqa) 13. 9%. The resulting in clinical studies displays that the cream cleaned the facial hair of 60% needless of female after using it on 24 weeks. In a phototoxicity study (25 subjects), irradiated sites showed either no reaction (40% of both sites treated with eflornithine HCl 13.9% cream and vehicle-treated sites), or mild erythema subsiding in all cases but one within 24 hours. Water: 6.6-8.6 %
Eflora Cream (Eflornithine HCL) is used by female patients to slow down undesirable hair growth. It is used to manage the condition, but does not permanently remove hair or cure the patient of further hair growth. Patients usually use Eflora Cream in combination with other treatments. Usual treatments includes that pull out, covered with wax and trichogen. The cream is effective to those women facial hairy because of heredopathia, excessive intake of androgen and polycystic ovary complications. The cream has special mechanism of action, it comes into play through interdicting the enzyme in follicle, which is integrant at the stage of development of facial hair.
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