The 4-epimer of Sancycline and a semi-synthetic antibiotic related to Tetracycline.
Specification: Enterprise Standard; Sancycline: Not less than 80%; Molecular Formula: C21H22N2O7
The subject product, Sancycline, is a semi-synthetic antibiotic derived from . The applicable subheading for Sancycline, imported in bulk form, will be . Molecular Weight: 414.41; Appearance: yellow crystalline powder
Synonyms: (4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide. Epi-sancycline: Not more than 15% This invention relates to methods and products for enhancing the effectiveness of antibiotics, more particularly, to methods and products for overcoming bacterial resistance to antibiotics of the tetracycline family.
Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking agents of doxycycline or sancycline, thereby increasing the sensitivity of the resistant cell to tetracycline type antibiotics. Loss on Drying: Not more than 18%.
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