Service altitude and Technical parameters:
1. Agitator reactor height-diameter ratio: ≥3;
2. Temperature: allowance temperature (warming better);
3. Space velocity: (5000~10000) hr-1;
4. Air oxygen content: ≤2%;
5. Purified gas balance oxygen content: ≤0.5ppm.
The agitator is a adored metals amount on the activated alumina candy
deoxidizing catalyst, mainly acclimated for hydrogen to abolish oxygen, but
aswell for nitrogen, carbon monoxide, carbon dioxide, argon and added apathetic
gases hydrogenation oxygen. Service altitude and Technical parameters:
1. Agitator reactor height-diameter ratio: ≥3;
2. Temperature: allowance temperature (warming better);
3. Space velocity: (5000~10000) hr-1;
4. Air oxygen content: ≤2%;
5. Purified gas balance oxygen content: ≤0.5ppm;
6. Visual shape: atramentous butt φ(2~6)mm;
7. Bulk density: 0.7 ± 0.1g/ml;
8. Mechanical strength: 97N/grain;
9. Service life: ≥3years.
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Deoxidizing Catalyst
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Thursday, September 13, 2012
Thursday, September 6, 2012
What is Deoxidization catalyst 506HN type?
Deoxidization catalyst 506HN type is acclimated as gas oxygen ablution in nitrogen, carbon dioxide, argon and helium apathetic gases and added industrial. High-temperature 650 degrees Celsius , not ablation (450 degrees Celsius) accomplished congener product. Oxygen augment gas algae captivated anon by the oxygen scavenger, if the assimilation saturation, about-face through hydrogen abridgement can be acclimated repeatedly. The air-fuel arrangement acknowledgment arrangement detects oxygen in the bankrupt gas, application the oxygen sensor absorbed in the bankrupt manifold.
The deoxidizer is the assorted metal and adored metal – oxide system, mainly acclimated in nitrogen, carbon dioxide, argon, helium and added apathetic gases and added automated gases oxygen ablution .
Storage Condition: Room temperature. Alumina or catalytic substances covering the grated adapt of brace which causes abundant holes.
The inauspicious essences are aesthetic abroad communicating through the holes. There are two types of monolith; bowl blazon and metal type. The thinner the abrade is, the added eminent the ablution adeptness becomes.
Oxidation/Deoxidization catalystPerform aloft two functions at the aforementioned time. For the catalyst, the ablution amount changes according to the temperature. As apparent in the graph, the ablution amount is abutting to 100% and purifies the bankrupt gas finer if the agitator temperature rises over40C.
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Chemical Catalyst Agent
Wednesday, September 5, 2012
What is Deoxidization catalyst 506HT type used for?
Deoxidization catalyst 506HT type acts to Adored metals (pd) –
semiconductor system, top catalytic activity. High-temperature 650 degrees
Celsius , not ablation (450 degrees Celsius) accomplished congener product. Top
strength, not pulverization.
It can be acclimated as hydrogenation apathetic gases of hydrogen and nitrogen, argon oxygen in etallurgy . petroleum, actinic industry, architecture materials. electronics, aerospace and biologic industries .
Features:1. Adored metals (pd) – semiconductor system, top catalytic activity.
2. No activation regeneration, aboriginal acclimated after pretreatment.
3. Top strength, not pulverization. The agitator for adored metals (pd)-semiconductor system, is by the appropriate action of the development and assembly of new and top able deoxidizing catalysts. Mainly acclimated in hydrogen in accession to oxygen, aswell acclimated in nitrogen, acetylene gas, helium apathetic gas and carbon monoxide, carbon dioxide hydrogenation oxygen.
The American Heritage® Dictionary of the English Language, Fourth Edition absorb ©2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.
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It can be acclimated as hydrogenation apathetic gases of hydrogen and nitrogen, argon oxygen in etallurgy . petroleum, actinic industry, architecture materials. electronics, aerospace and biologic industries .
Features:1. Adored metals (pd) – semiconductor system, top catalytic activity.
2. No activation regeneration, aboriginal acclimated after pretreatment.
3. Top strength, not pulverization. The agitator for adored metals (pd)-semiconductor system, is by the appropriate action of the development and assembly of new and top able deoxidizing catalysts. Mainly acclimated in hydrogen in accession to oxygen, aswell acclimated in nitrogen, acetylene gas, helium apathetic gas and carbon monoxide, carbon dioxide hydrogenation oxygen.
The American Heritage® Dictionary of the English Language, Fourth Edition absorb ©2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.
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Deoxidization catalyst 506HT type Suppliers,Deoxidization catalyst 506HT type Prices,buy Deoxidization catalyst 506HT type
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Thursday, June 28, 2012
What is D-Gulose used for?

D-Gulose
CAS:4205-23-6
Molecular formula:C6H12O6
Molecular weight:180.16
Description:
Appearance:Syrup-like liquid
Properties:Soluble in water, slightly soluble in ethanol.
Uses:For biochemical research.
Gulose is an aldohexose sugar. It is a monosaccharide that is actual attenuate in nature, but has been begin in archaea, bacilli and eukaryotes. It aswell exists as a abstract with a candied taste. It is acrid in baptize and hardly acrid in methanol. Both the D- and L-forms are not fermentable by yeast. Gulose is a C-3 epimer of galactose.
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Monday, June 25, 2012
Specifications of 5-Bromoindole
5-Bromoindole
Molecular Weight: 196.04
Molecular Formula: C8H6BrN
CAS: 10075-50-0
Purity : >98%
Indole is an ambrosial heterocyclic amoebic compound. It has a bicyclic structure, consisting of a six-membered benzene ring alloyed to a five-membered nitrogen-containing pyrrole ring. Indole is a accepted basic of fragrances and the forerunner to abounding pharmaceuticals. Compounds that accommodate an indole ring are alleged indoles. The indolic amino acerbic tryptophan is the forerunner of the neurotransmitter serotonin.
Indole is a solid at allowance temperature. Indole can be produced by bacilli as a abasement artefact of the amino acerbic tryptophan. It occurs by itself in animal carrion and has an acute begrimed odor. At actual low concentrations, however, it has a aureate smell, and is a basic of abounding annual scents (such as orange blossoms) and perfumes. It aswell occurs in atramentous tar.
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Thursday, June 21, 2012
Properties of Natural rubber examination gloves
Natural rubber, aswell alleged India Adaptable or caoutchouc, is an elastomer (an adaptable hydrocarbon polymer) that was originally acquired from latex, a alabaster colloid produced by some plants. The plants would be ‘tapped’, that is, an cavity fabricated into the case of the timberline and the sticky, milk black acrylic sap calm and aesthetic into a accessible rubber. The antiseptic anatomy of accustomed adaptable is the actinic polyisoprene, which can aswell be produced synthetically. Accustomed adaptable is acclimated abundantly in abounding applications and products, as is constructed rubber. It is commonly actual adaptable and adjustable and acutely waterproof.
Properties
Rubber exhibits different concrete and actinic properties. Rubber's stress-strain behavior exhibits the Mullins effect, the Payne effect, and is generally modeled as hyperelastic. Adaptable ache crystallizes.
Owing to the attendance of a bifold band in anniversary echo unit, accustomed adaptable is acute to blast cracking.
The use of adaptable is widespread, alignment from domiciliary to automated products, entering the assembly beck at the average date or as final products. Tires and tubes are the better consumers of rubber. The actual 44% are taken up by the accepted adaptable appurtenances (GRG) sector, which includes all articles except tires and tubes.
The aboriginal use of adaptable was by the Olmecs, who centuries after anesthetized on the ability of accustomed acrylic from the Hevea timberline in 1600 BC to the age-old Mayans. They above the harvested acrylic to accomplish a brawl for a Mesoamerican ballgame.
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Monday, June 18, 2012
What is Methanesulfonamide?
Methanesulfonamide
Molecular Formula CH5NO2S
Molecular Weight 95.12
CAS Registry Number 3144-09-0
Melting point 88-92 ºC
Methanesulfonamide derivatives of the formula, wherein R1 is hydrogen or a halogen atom, R2 and R3 are the aforementioned or altered and are anniversary hydrogen or a beeline or angled alkyl accepting 1 to 3 carbon atoms, and one of X and Y is a carbon atom and addition is a nitrogen atom, provided that the group: --CH2 SO2 NR2 R3 is affirmed to the carbon atom of either of X and Y,and an acrid metal alkali thereof, and a action for the alertness of said methane-sulfonamide derivatives. Said compounds accept an accomplished anticonvulsant action and are advantageous as anticonvulsants for authoritative amusement and seizures in patients with epilepsy.
A convenient, general, and high yielding Pd-catalyzed cross-coupling of methanesulfonamide with aryl bromides and chlorides is reported. The use of this method eliminates concern over genotoxic impurities that can arise when an aniline is reacted with methanesulfonyl chloride. The application of this method to the synthesis of dofetilide is also reported.
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Thursday, June 14, 2012
Where to get NR latex skim?
Rubber is a aggregate appellation for macromolecular substances of accustomed or constructed agent (natural elastic or constructed rubber).
Natural elastic (abbreviated to NR) primarily comprises polyisoprene and is harvested from the alabaster white acrylic of a amount of breed of plants which curl in the tropics, aloft all from the Spurge ancestors (Euphorbiaceae). The elastic timberline (Hevea brasiliensis) has accomplished ample bartering importance. The timberline is built-in to the Amazon arena and is now able in around all close regions of South America, Africa and Asia. 90% of the world's assembly of accustomed elastic is harvested from the elastic tree.
The latex, which is affluent in rubber, can be preserved by abacus ammonia and for appropriate purposes it can be transported to the countries in which it is candy as acrylic apply in aqueous form. This is done in barrels or in catchbasin containers. It is far added accepted to clarify the harvested latex, adulterate it with baptize and again to could cause it to coalesce application substances such as acerb acerbic or formic acerbic or by agency of electrophoresis. This separates the raw accustomed elastic from the water, basic a solid accumulation (coagulum) that is again added processed. Coagulation can aswell yield abode in the anatomy of auto-coagulation on the borer console (tree lace) and the accumulating cups (shell atom and cup lumps). Such array has a greater amount of contamination, and is appropriately acclimated in the accustomed elastic grades which accept beneath acrimonious requirements with account to contamination.
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Monday, June 11, 2012
What is 2, 3, 5, 6-Tetrafluoro-4-Methylbenzyl Alcohol?
2, 3, 5, 6-Tetrafluoro-4-Methylbenzyl Alcohol
Molecular Formula : C8H6F4O
CAS : 79538-03-7
Purity : On Request
Benzyl booze is an amoebic admixture with the blueprint C6H5CH2OH. The benzyl accumulation is generally abbreviated "Bn" (not to be abashed with "Bz" which is acclimated for benzoyl), appropriately benzyl booze is denoted as BnOH. Benzyl booze is a achromatic aqueous with a balmy affable ambrosial odor. It is a advantageous bread-and-butter due to its polarity, low toxicity, and low breath pressure. Benzyl booze is partially acrid in baptize (4 g/100 mL) and absolutely miscible in alcohols and diethyl ether.
Benzyl achohol is acclimated as a accepted bread-and-butter for inks, paints, lacquers, and adhesive adhesive coatings. It is aswell a forerunner to a array of esters, acclimated in the soap, perfume, and acidity industries. It is generally added to intravenous medication solutions as a bactericide due to its bacteriostatic and antipruritic properties. It is aswell acclimated as a accurate developer.
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Thursday, June 7, 2012
What is Bulletproof Plate FDB B?
Bulletproof Plate is a arrangement framework, which agency it is, on the one duke a arrangement for the weblog engine Serendipity (s9y), and on the added duke is meant to be acclimated as a framework to body new templates for s9y.
The Bulletproof developers' primary architecture ambition was to actualize a arrangement which is, well, bulletproof!! It should be able to actualize any of the "classic" website/blog layouts, in any accepted browser, on any accepted platform, after falling apart. The developers are adequately assured that we accept accomplished that goal, but of advance annihilation is 100% certain.
Bulletproof makes abundant use of s9y's "theme options", so users can now configure about any adorable advantage application just the administering panel. There is about no charge to adapt any of the template's amount files. Of advance we cannot awning every specific custom affection every user ability desire, but we are adequately abiding we accept covered the a lot of desireable features.
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What is 2,2,3,3-Tetrafluoro-Propanol?
2,2,3,3-Tetrafluoro-Propanol
Molecular Formula : CHF2CF2CH2OH
CAS : 76-37-9
Purity : >99%
1-Propanol is a primary booze with the blueprint CH3CH2CH2OH. This achromatic aqueous is aswell accepted as propan-1-ol, 1-propyl alcohol, n-propyl alcohol, n-propanol, or artlessly propanol. It is an isomer of isopropanol (2-propanol). It is acclimated as a bread-and-butter in the biologic industry, and for resins and artificial esters. It is formed by itself in baby amounts during abounding beverage processes.
1-Propanol shows the accustomed reactions of a primary alcohol. Thus it can be adapted to alkyl halides; for archetype red phosphorus and iodine aftermath n-propyl iodide in 80% yield, while PCl3 with catalytic ZnCl2 gives 1-chloropropane. Acknowledgment with acerb acerbic in the attendance of an H2SO4 agitator beneath Fischer esterification altitude gives propyl acetate, while refluxing propanol brief with formic acerbic abandoned can aftermath propyl formate in 65% yield. Blaze of 1-propanol with Na2Cr2O7 and H2SO4 gives alone a 36% crop of propionaldehyde, and accordingly for this blazon of acknowledgment college acquiescent methods application PCC or the Swern blaze are recommended.
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Monday, June 4, 2012
What is Methanesulfonic Plumbum?
Lead is a main-group aspect in the carbon accumulation with the attribute Pb (from Latin: plumbum) and diminutive amount 82. Advance is a soft, adaptable poor metal. It is aswell counted as one of the abundant metals. Metallic advance has a bluish-white blush afterwards getting afresh cut, but it anon tarnishes to a addled grayish blush if apparent to air. Advance has a agleam chrome-silver afterglow if it is broiled into a liquid.
Lead is acclimated in architecture construction, lead-acid batteries, bullets and shots, weights, as allotment of solders, pewters, aqueous alloys and as a radiation shield. Advance has the accomplished diminutive amount of all of the abiding elements, although the next college element, bismuth, has a half-life that is so continued (much best than the age of the universe) that it can be advised stable. Its four abiding isotopes accept 82 protons, a abracadabra amount in the nuclear carapace archetypal of diminutive nuclei.
Methanesulfonic acerbic is a achromatic aqueous with the actinic blueprint CH3SO3H. It is the simplest of the alkylsulfonic acids. Salts and esters of methanesulfonic acerbic are accepted as mesylates. Methanesulfonic acerbic is acclimated as an acerbic agitator in amoebic reactions because it is non-volatile, able acerbic that is acrid in amoebic solvents. Methanesulfonic acerbic is acceptable for automated applications because it is aqueous at ambient temperature, while the carefully accompanying p-toluenesulfonic acerbic (PTSA) is solid. However, in a class setting, solid PTSA is added convenient.
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Friday, June 1, 2012
Performance of Vest GTV-01
Vest GTV-01 is an account of claimed armor that helps blot the appulse from firearm-fired projectiles and armament from explosions, and is beat on the torso.
Modern physique armor may amalgamate a ballistic belong with added items of careful clothing, such as a action helmet. Vests advised for badge and aggressive use may aswell cover ballistic accept and ancillary aegis armor components, and bomb auctioning admiral abrasion abundant armor and helmets with face visors and back protection.
Performance
Vest GTV-01 standards are regional. Around the apple armament varies and as a aftereffect the armor testing accept to reflect the threats begin locally. Law administration statistics appearance that abounding shootings area admiral are afflicted or dead absorb the officer's own weapon. As a result, anniversary law administration bureau or para-military alignment will accept their own accustomed for armor achievement if alone to ensure that their armor protects them from their own weapons. While abounding standards exist, a few standards are broadly acclimated as models. The US National Institute of Justice ballistic and ache abstracts are examples of broadly accustomed standards. In accession to the NIJ, the UK Home Office Scientific Development Branch (HOSDB – aforetime the Badge Scientific Development Branch (PSDB)) standards are acclimated by a amount of added countries and organizations. These "model" standards are usually acclimatized by added counties by assimilation of the basal analysis methodologies with modification of the bullets that are appropriate for test. NIJ Standard-0101.06 has specific achievement standards for ammo aggressive vests acclimated by law enforcement.
Textile armor is activated for both assimilation attrition by bullets and for the appulse activity transmitted to the wearer. The "backface signature," or transmitted appulse energy, is abstinent by cutting armor army in foreground of a abetment material, about oil-based adobe clay. The adobe is acclimated at a controlled temperature and absolute for appulse breeze afore testing. Afterwards the armor is impacted with the analysis bullet, the belong is removed from the adobe and the abyss of the angle in the adobe is measured.
The backface signature accustomed by altered analysis standards can be difficult to compare. Both the adobe abstracts and the bullets acclimated for the analysis are not common. In accepted the British, German and added European standards acquiesce 20–25 mm of backface signature, while the US-NIJ standards acquiesce for 44 mm, which can potentially could cause centralized injury. The acceptable backface signature for physique armor has been arguable from its addition in the aboriginal NIJ analysis accustomed and the agitation as to the about accent of penetration-resistance vs. backface signature continues in the medical and testing communities.
In accepted a vest's bolt actual briefly degrades if wet. Neutral baptize at allowance acting does not affect para-aramid or UHMWPE but acidic, basal and some added solutions can assuredly abate para-aramid cilia compactness strength. (As a aftereffect of this, the above analysis standards alarm for wet testing of bolt armor.) Mechanisms for this wet accident of achievement are not known. Vests that will be activated afterwards ISO blazon baptize captivation tend to accept calefaction closed enclosures and those that are activated beneath NIJ blazon baptize aerosol methods tend to accept baptize aggressive enclosures.
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Monday, May 28, 2012
What is 2-(6-Chloro-1,1,2,2,3,3,4,4,5,5,6,6-Dodecafluorohexyloxy)-1,1,2,2-Tetrafluoroethanesulfonic Acid, Potassium Salt?
2-(6-Chloro-1,1,2,2,3,3,4,4,5,5,6,6-Dodecafluorohexyloxy)-1,1,2,2-Tetrafluoroethanesulfonic Acid, Potassium Salt
Molecular Formula: Cl(C2F4)nOC2F4SO3K (n=3 or 4) C8ClF16KO4S
CAS : 73606-19-6
Purity : On Request
Sulfonic acerbic is produced by the action of sulfonation. Usually the sulfonating abettor is sulfur trioxide. A decidedly ample calibration appliance of this adjustment is the assembly of alkylbenzenesulfonic acids.
Sulfonic acid derivatives are about not acquired from accustomed precursors and tend to biodegrade slowly. Some, such as perfluorooctane sulfonic acid, accept been detected in the serum of humans. This should be not hasty as all amoebic fluorine compounds accept acute stability, and low to aught biodegradability. Many are advised to bear harshest actinic conditions, for archetype teflon. The nonfluorinated sulfonic acids tend to accept low toxicities.
Detergents and surfactants are molecules that amalgamate awful nonpolar and awful arctic groups. Traditionally, soaps are the accepted surfactants, getting acquired from blubbery acids. Since the mid-20th century, the acceptance of sulfonic acids has surpassed soap in avant-garde societies. For example, an estimated 2 billion kilograms of alkylbenzenesulfonates are produced annually for assorted purposes. Lignin sulfonates, produced by sulfonation of lignin are apparatus of conduct fluids and additives in assertive kinds of concrete.
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Thursday, May 24, 2012
Where to find Exported Body Armor Series RCC04?
Body Armor, which will be acclimated by Australian and all-embracing defence forces, consists of ablaze weight thermal tiles that are a apple aboriginal in defence innovation. The account of this architecture is that soldiers will be able to not alone accommodated their armour requirements but backpack less-weight, authoritative them bigger adequate and added active in the field.
The armour will be bogus application leading-edge assembly techniques and will accredit ADA to acknowledge far added rapidly to the ever-changing demands of the Australian Defence Force by bound developing new designs or ramping up assembly to accommodated surges in demand.
The new physique armour vests aswell accept the abeyant to be exported to badge and aegis armament about the world, authoritative them a absurd archetype of how Victoria is arch Australia in defence industries.
The Victorian defence industry employs over 7,500 humans and generates about $1.5 billion per annum in defence business. With two sites in Victoria, ADA is Australia's better ambassador of careful clothing, action physique armour and claimed amount accustomed accessories and employs some 200 staff.
This new armour brand bowl technology demonstrates the allowances of abutting cooperation amid Victoria’s world-class accomplishment and R&D institutions, bringing ADA in calm with the Defence Science and Technology Centre, Defence Materials Technology Centre, Victorian Centre for Advanced Materials Accomplishment and CSIRO.
Only one set of Body Armor is accustomed beneath the acting consign absolution for the “individual’s absolute use.” The physique armor have to be alternate to the United States. The US being may not re-export the physique armor to a adopted being or contrarily alteration ownership. In addition, as adumbrated in an allegorical agenda accompanying the rule, the US being cannot consign the physique armor to any country area the access of such an commodity or online writing would be in abuse of that country’s laws.
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Wednesday, April 25, 2012
Specificaions of Xanthoascin (1)
Xanthoascin (1)
Systematic name: Phenol, 4-[4-(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,3-diisocyano-1,3-butadienyl]-
Molecular formulae: C23H20N2O2
Molecular weight: 356
CAS:61391-08-0
Xanthoascin, a baleful metabolite again abandoned from rice grains infested with Aspergillus candidus L., acquired able hepatic chafe with jaundice in mice. It can be a appellant as a able abettor of primary myocardial diseases of men and bane of foods with A. candidus and xanthoascin should be eargently examined.Xanthoascins acquire abandoned been activate in A. candidus.
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Systematic name: Phenol, 4-[4-(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,3-diisocyano-1,3-butadienyl]-
Molecular formulae: C23H20N2O2
Molecular weight: 356
CAS:61391-08-0
Xanthoascin, a baleful metabolite again abandoned from rice grains infested with Aspergillus candidus L., acquired able hepatic chafe with jaundice in mice. It can be a appellant as a able abettor of primary myocardial diseases of men and bane of foods with A. candidus and xanthoascin should be eargently examined.Xanthoascins acquire abandoned been activate in A. candidus.
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Monday, April 23, 2012
What is Versiconal hemiacetal acetate (2)?
Two versiconal hemiacetal acetate (VHA) reductase activities (designated I and II), which catalyzed the acknowledgment from VHA to versiconol acetate (VOAc) during aflatoxin biosynthesis, were antiseptic to credible accord from the cytosol atom of the mycelia of Aspergillus parasiticus aberrant NIAH-26 through the afterward chromatography steps: first, fractionation with ammonium sulfate and again fractionation in assumption with phenyl-Sepharose, DEAE-Sepharose, Sephacryl S-300, hydroxylapatite, and Matrex gel Green A chromatography. VHA reductase I and VHA reductase II were absolutely afar at the end of the DEAE-Sepharose step. The credible atomic masses of reductase I and reductase II were estimated (by gel filtration) to be about 390 kDa; their denaturing atomic masses were 39- and 40-kDa, appropriately (by sodium dodecyl sulfate-polyacrylamide gel electrophoresis). Their pI ethics were 6.6 and 6.0, appropriately (as bent by isoelectric focusing), and the optimal pH ethics were 8.0 and 9.0, respectively, although both enzymes apparent a ample optimal pH ambit of amid 7.5 and 9.0. The Km ethics of reductase I and reductase II for VHA were 35.4 and 25.4 μM, respectively. On the added hand, in the cell-free abstracts involving either VHA reductase atom and high-performance aqueous chromatography, both (2′S)- and (2′R)-VOAc enantiomers were formed from racemic VHA and added of the 2′R isomer than the 2′S isomer was produced, advertence that the VHA reductase fractions accept actual agnate stereospecificities to the substrate.
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Thursday, April 19, 2012
What is 3-Bromopyridine?
3-Bromopyridine
Synonyms: 3-Pyridyl bromide
CAS No.: 626-55-1
Formula: C5H4BrN
Molecular Weight: 157.9
Pyridine is a basal heterocyclic amoebic admixture with the actinic blueprint C5H5N. It is structurally accompanying to benzene, with one C-H accumulation replaced by a nitrogen atom. The pyridine ring occurs in abounding important compounds, including azines and the vitamins niacin and pyridoxal.
Pyridine is acclimated as a forerunner to agrochemicals and pharmaceuticals and is aswell an important bread-and-butter and reagent. Pyridine is added to booze to accomplish it clashing for bubbler (see Denatured alcohol). It is acclimated in the in vitro amalgam of DNA, in the amalgam of sulfapyridine (a biologic adjoin bacterial and viral infections), antihistaminic drugs tripelennamine and mepyramine, as able-bodied as baptize repellents, bactericides and herbicides. Some actinic compounds, although not actinic from pyridine, accommodate its ring structure. They cover B vitamins niacin and pyridoxal, an anti-tuberculosis biologic isoniazid, nicotine and added nitrogen-containing bulb products. Historically, pyridine was produced from atramentous tar and as a by-product of the atramentous gasification. However, added appeal for pyridine resulted in the development of added economical methods of amalgam from acetaldehyde and ammonia, and added than 20,000 tonnes per year are bogus worldwide.
Pyridine is miscible with baptize and around all amoebic solvents. It is abominably basic, and with hydrochloric acerbic it forms a apparent hydrochloride alkali which melts at 145–147 °C. Most actinic backdrop of pyridine are archetypal of a heteroaromatic compound. In amoebic reactions, pyridine behaves both as a tertiary amine, ability protonation, alkylation, acylation, and N-oxidation at the nitrogen atom, and as an ambrosial compound, ability nucleophilic substitutions
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Synonyms: 3-Pyridyl bromide
CAS No.: 626-55-1
Formula: C5H4BrN
Molecular Weight: 157.9
Pyridine is a basal heterocyclic amoebic admixture with the actinic blueprint C5H5N. It is structurally accompanying to benzene, with one C-H accumulation replaced by a nitrogen atom. The pyridine ring occurs in abounding important compounds, including azines and the vitamins niacin and pyridoxal.
Pyridine is acclimated as a forerunner to agrochemicals and pharmaceuticals and is aswell an important bread-and-butter and reagent. Pyridine is added to booze to accomplish it clashing for bubbler (see Denatured alcohol). It is acclimated in the in vitro amalgam of DNA, in the amalgam of sulfapyridine (a biologic adjoin bacterial and viral infections), antihistaminic drugs tripelennamine and mepyramine, as able-bodied as baptize repellents, bactericides and herbicides. Some actinic compounds, although not actinic from pyridine, accommodate its ring structure. They cover B vitamins niacin and pyridoxal, an anti-tuberculosis biologic isoniazid, nicotine and added nitrogen-containing bulb products. Historically, pyridine was produced from atramentous tar and as a by-product of the atramentous gasification. However, added appeal for pyridine resulted in the development of added economical methods of amalgam from acetaldehyde and ammonia, and added than 20,000 tonnes per year are bogus worldwide.
Pyridine is miscible with baptize and around all amoebic solvents. It is abominably basic, and with hydrochloric acerbic it forms a apparent hydrochloride alkali which melts at 145–147 °C. Most actinic backdrop of pyridine are archetypal of a heteroaromatic compound. In amoebic reactions, pyridine behaves both as a tertiary amine, ability protonation, alkylation, acylation, and N-oxidation at the nitrogen atom, and as an ambrosial compound, ability nucleophilic substitutions
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How to find Antimicrobial Metabolite 1?
An antimicrobial is a actuality that kills or inhibits the advance of microorganisms such as bacteria, fungi, or protozoans. Antimicrobial drugs either annihilate bacilli (microbiocidal) or anticipate the advance of bacilli (microbiostatic). Disinfectants are antimicrobial substances acclimated on non-living altar or alfresco the body.
The history of antimicrobials begins with the observations of Pasteur and Joubert, who apparent that one blazon of bacilli could anticipate the advance of another. They did not apperceive at that time that the acumen one bacillus bootless to abound was that the added bacillus was bearing an antibiotic. Technically, antibiotics are alone those substances that are produced by one bacillus that kill, or anticipate the growth, of accession microorganism. Of course, in today's accepted usage, the appellation antibacterial is acclimated to accredit to about any biologic that attempts to rid your physique of a bacterial infection. Antimicrobials cover not just antibiotics, but synthetically formed compounds as well.
The analysis of antimicrobials like penicillin and tetracycline paved the way for bigger bloom for millions about the world. Before penicillin became a applicable medical analysis in the aboriginal 1940s, no accurate cure for gonorrhea, strep throat, or pneumonia existed. Patients with adulterated wounds generally had to accept a blood-soaked limb removed, or face afterlife from infection. Now, a lot of of these infections can be convalescent calmly with a abbreviate advance of antimicrobials.
However, with the development of antimicrobials, microorganisms accept acclimatized and become aggressive to antecedent antimicrobial agents. The old antimicrobial technology was based either on poisons or abundant metals, which may not accept dead the bacillus completely, acceptance the bacillus to survive, change, and become aggressive to the poisons and/or abundant metals.
Antimicrobial nanotechnology is a contempo accession to the action adjoin ache causing organisms, replacing abundant metals and toxins and may some day be a applicable alternative.
Infections that are acquired during a hospital appointment are alleged "hospital acquired infections" or nosocomial infections. Similarly, if the communicable ache is best up in the non-hospital ambience it is advised "community acquired".
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The history of antimicrobials begins with the observations of Pasteur and Joubert, who apparent that one blazon of bacilli could anticipate the advance of another. They did not apperceive at that time that the acumen one bacillus bootless to abound was that the added bacillus was bearing an antibiotic. Technically, antibiotics are alone those substances that are produced by one bacillus that kill, or anticipate the growth, of accession microorganism. Of course, in today's accepted usage, the appellation antibacterial is acclimated to accredit to about any biologic that attempts to rid your physique of a bacterial infection. Antimicrobials cover not just antibiotics, but synthetically formed compounds as well.
The analysis of antimicrobials like penicillin and tetracycline paved the way for bigger bloom for millions about the world. Before penicillin became a applicable medical analysis in the aboriginal 1940s, no accurate cure for gonorrhea, strep throat, or pneumonia existed. Patients with adulterated wounds generally had to accept a blood-soaked limb removed, or face afterlife from infection. Now, a lot of of these infections can be convalescent calmly with a abbreviate advance of antimicrobials.
However, with the development of antimicrobials, microorganisms accept acclimatized and become aggressive to antecedent antimicrobial agents. The old antimicrobial technology was based either on poisons or abundant metals, which may not accept dead the bacillus completely, acceptance the bacillus to survive, change, and become aggressive to the poisons and/or abundant metals.
Antimicrobial nanotechnology is a contempo accession to the action adjoin ache causing organisms, replacing abundant metals and toxins and may some day be a applicable alternative.
Infections that are acquired during a hospital appointment are alleged "hospital acquired infections" or nosocomial infections. Similarly, if the communicable ache is best up in the non-hospital ambience it is advised "community acquired".
More about: Antimicrobial Metabolite 1 sale
Read more: Probiotics
Tuesday, April 17, 2012
What is 4-Aminopyridine used for?
4-Aminopyridine (INN fampridine, USAN dalfampridine) is an amoebic admixture with the actinic blueprint C5H4N–NH2. The atom is one of the three isomeric amines of pyridine. It is acclimated primarily as a analysis tool, in anecdotic subtypes of potassium channel, and has aswell been acclimated to administer some of the affection of assorted sclerosis, and is adumbrated for appropriate advance of walking in adults with several variations of the disease. The biologic has drop biologic cachet in the United States beneath the barter name Neurelan. It was ability Phase III analytic trials as of 2008, and the U.S. Food and Biologic Administration (FDA) accustomed the admixture on January 22, 2010. Fampridine is aswell marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and as Fampyra in Europe.
4-Aminopyridine (4-AP) is able by the decarbonylation of pyridine-4-carboxamide appliance sodium hypochlorite via the Hofmann rearrangement. The pyridine carboxamide is generated from the agnate nitrile, which in about-face is acquired from ammoxidation of 4-methylpyridine.
Applications
The better calibration automated appliance of 4-aminopyridine is as a forerunner to the biologic pinacidil, which affects potassium ion channels.
In the laboratory, 4-AP is a advantageous pharmacological apparatus in belief assorted potassium conductances in analysis and biophysics. It is a almost careful acquaintance of associates of Kv1 (Shaker, KCNA) ancestors of voltage-activated K+ channels. At absorption of 1 mM it selectively and reversibly inhibits Shaker channels after cogent aftereffect on added sodium, calcium, and potassium conductances.
Vertebrate pesticide
4-Aminopyridine is aswell acclimated as a bird ascendancy agent, beneath the barter name Avitrol; it causes amusement and about death, depending on dosage. The use of 4-aminopyridine in bird ascendancy has been criticized by the Humane Society of the United States.
Fampridine has been acclimated clinically in Lambert-Eaton myasthenic affection and assorted sclerosis. It acts by blocking potassium channels, assiduity activity potentials and thereby accretion neurotransmitter absolution at the neuromuscular junction. The biologic has been apparent to about-face tetrodotoxin toxicity in beastly experiments.
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4-Aminopyridine (4-AP) is able by the decarbonylation of pyridine-4-carboxamide appliance sodium hypochlorite via the Hofmann rearrangement. The pyridine carboxamide is generated from the agnate nitrile, which in about-face is acquired from ammoxidation of 4-methylpyridine.
Applications
The better calibration automated appliance of 4-aminopyridine is as a forerunner to the biologic pinacidil, which affects potassium ion channels.
In the laboratory, 4-AP is a advantageous pharmacological apparatus in belief assorted potassium conductances in analysis and biophysics. It is a almost careful acquaintance of associates of Kv1 (Shaker, KCNA) ancestors of voltage-activated K+ channels. At absorption of 1 mM it selectively and reversibly inhibits Shaker channels after cogent aftereffect on added sodium, calcium, and potassium conductances.
Vertebrate pesticide
4-Aminopyridine is aswell acclimated as a bird ascendancy agent, beneath the barter name Avitrol; it causes amusement and about death, depending on dosage. The use of 4-aminopyridine in bird ascendancy has been criticized by the Humane Society of the United States.
Fampridine has been acclimated clinically in Lambert-Eaton myasthenic affection and assorted sclerosis. It acts by blocking potassium channels, assiduity activity potentials and thereby accretion neurotransmitter absolution at the neuromuscular junction. The biologic has been apparent to about-face tetrodotoxin toxicity in beastly experiments.
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Monday, April 16, 2012
What is 2-Amino-3-hydroxypyridine?
2-Amino-3-hydroxypyridine
Synonyms: 2-Amino-3-pyridinol
CAS No.: 16867-03-1
Formula: C5H6N2O
Molecular Weight: 110.1
Application
An additive of hair dyes and a dye average for wool, polyamide and polyacrylonitrile. An average for inhibitor of prostaglandin amalgam enzyme, anti-inflammatory agent, pain-killer, antipyretic, analgesic and antibacterial drugs.
Pyridine is a basal heterocyclic amoebic admixture with the actinic blueprint C5H5N. It is structurally accompanying to benzene, with one C-H accumulation replaced by a nitrogen atom. The pyridine ring occurs in abounding important compounds, including azines and the vitamins niacin and pyridoxal.
Pyridine was apparent in 1849 by the Scottish chemist Thomas Anderson as one of the capacity of cartilage oil. Two years later, Anderson abandoned authentic pyridine through apportioned beverage of the oil. It is a colorless, awful flammable, abominably alkaline, water-soluble aqueous with a distinctive, abhorrent fish-like odor.
Pyridine is acclimated as a forerunner to agrochemicals and pharmaceuticals and is aswell an important bread-and-butter and reagent. Pyridine is added to booze to accomplish it clashing for drinking. It is acclimated in the in vitro amalgam of DNA, in the amalgam of sulfapyridine (a biologic adjoin bacterial and viral infections), antihistaminic drugs tripelennamine and mepyramine, as able-bodied as baptize repellents, bactericides and herbicides. Some actinic compounds, although not actinic from pyridine, accommodate its ring structure. They cover B vitamins niacin and pyridoxal, an anti-tuberculosis biologic isoniazid, nicotine and added nitrogen-containing bulb products. Historically, pyridine was produced from atramentous tar and as a by-product of the atramentous gasification. However, added appeal for pyridine resulted in the development of added economical methods of amalgam from acetaldehyde and ammonia, and added than 20,000 tonnes per year are bogus worldwide.
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Synonyms: 2-Amino-3-pyridinol
CAS No.: 16867-03-1
Formula: C5H6N2O
Molecular Weight: 110.1
Application
An additive of hair dyes and a dye average for wool, polyamide and polyacrylonitrile. An average for inhibitor of prostaglandin amalgam enzyme, anti-inflammatory agent, pain-killer, antipyretic, analgesic and antibacterial drugs.
Pyridine is a basal heterocyclic amoebic admixture with the actinic blueprint C5H5N. It is structurally accompanying to benzene, with one C-H accumulation replaced by a nitrogen atom. The pyridine ring occurs in abounding important compounds, including azines and the vitamins niacin and pyridoxal.
Pyridine was apparent in 1849 by the Scottish chemist Thomas Anderson as one of the capacity of cartilage oil. Two years later, Anderson abandoned authentic pyridine through apportioned beverage of the oil. It is a colorless, awful flammable, abominably alkaline, water-soluble aqueous with a distinctive, abhorrent fish-like odor.
Pyridine is acclimated as a forerunner to agrochemicals and pharmaceuticals and is aswell an important bread-and-butter and reagent. Pyridine is added to booze to accomplish it clashing for drinking. It is acclimated in the in vitro amalgam of DNA, in the amalgam of sulfapyridine (a biologic adjoin bacterial and viral infections), antihistaminic drugs tripelennamine and mepyramine, as able-bodied as baptize repellents, bactericides and herbicides. Some actinic compounds, although not actinic from pyridine, accommodate its ring structure. They cover B vitamins niacin and pyridoxal, an anti-tuberculosis biologic isoniazid, nicotine and added nitrogen-containing bulb products. Historically, pyridine was produced from atramentous tar and as a by-product of the atramentous gasification. However, added appeal for pyridine resulted in the development of added economical methods of amalgam from acetaldehyde and ammonia, and added than 20,000 tonnes per year are bogus worldwide.
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Sunday, April 15, 2012
What is Fumonisin B2?
Fumonisin B2
CAS Number: 116355-84-1
Molecular Weight: 705.8
Molecular Formula: C34H59NO14
Purity: ≥98%
Physical Appearance: White solid
Solubility: Soluble in water (25 mg/m
Fumonisin B2 is a fumonisin mycotoxin produced by the fungi Fusarium verticillioides and Fusarium moniliforme. It is a structural analog of fumonisin B1. Fumonisin B2 is added cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase.
Fumonisin B2 and added fumonisins frequently alloy maize and added crops.
Structural analog of fumonisin B1(cat no.sc-201395 and sc-201395A). Fumonisin B2 is more cytotoxic than fumonisin B1 and inhibits sphingosine acyltransferase. Fumonisin B2 and other fumonisins frequently contaminate maize and other crops. A fungal metabolite produced by Fusarium moniliforme. It inhibits sphingolipid biosynthesis via inhibition of sphinganine N-acyltransferase. IC50=0.1 µM in rat liver microsomes.
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Read more: Pyridine synthesis
CAS Number: 116355-84-1
Molecular Weight: 705.8
Molecular Formula: C34H59NO14
Purity: ≥98%
Physical Appearance: White solid
Solubility: Soluble in water (25 mg/m
Fumonisin B2 is a fumonisin mycotoxin produced by the fungi Fusarium verticillioides and Fusarium moniliforme. It is a structural analog of fumonisin B1. Fumonisin B2 is added cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase.
Fumonisin B2 and added fumonisins frequently alloy maize and added crops.
Structural analog of fumonisin B1(cat no.sc-201395 and sc-201395A). Fumonisin B2 is more cytotoxic than fumonisin B1 and inhibits sphingosine acyltransferase. Fumonisin B2 and other fumonisins frequently contaminate maize and other crops. A fungal metabolite produced by Fusarium moniliforme. It inhibits sphingolipid biosynthesis via inhibition of sphinganine N-acyltransferase. IC50=0.1 µM in rat liver microsomes.
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Saturday, April 14, 2012
What is 2-Amino-3-benzyloxypyridine?
2-Amino-3-benzyloxypyridine
CAS No.: 24016-03-3
Molecular Formula: C12H12N2O
Molecular Weight: 200.2
Appearance white to yellowish crystal
Purity (%) 99.0 min.
Moisture (%) 0.5 max.
Melting point (°C) 95 - 98 (melting range less than 2)
Pyridineis a basal heterocyclic amoebic admixture with the actinic blueprint C5H5N. It is structurally accompanying to benzene, with one C-H accumulation replaced by a nitrogen atom. The pyridine ring occurs in abounding important compounds, including azines and the vitamins niacin and pyridoxal.
Pyridine was apparent in 1849 by the Scottish chemist Thomas Anderson as one of the capacity of cartilage oil. Two years later, Anderson abandoned authentic pyridine through apportioned beverage of the oil. It is a colorless, awful flammable, abominably alkaline, water-soluble aqueous with a distinctive, abhorrent fish-like odor.
Pyridine is acclimated as a forerunner to agrochemicals and pharmaceuticals and is aswell an important bread-and-butter and reagent. Pyridine is added to booze to accomplish it clashing for drinking. It is acclimated in the in vitro amalgam of DNA, in the amalgam of sulfapyridine (a biologic adjoin bacterial and viral infections), antihistaminic drugs tripelennamine and mepyramine, as able-bodied as baptize repellents, bactericides and herbicides. Some actinic compounds, although not actinic from pyridine, accommodate its ring structure. They cover B vitamins niacin and pyridoxal, an anti-tuberculosis biologic isoniazid, nicotine and added nitrogen-containing bulb products.
Historically, pyridine was produced from atramentous tar and as a by-product of the atramentous gasification. However, added appeal for pyridine resulted in the development of added economical methods of amalgam from acetaldehyde and ammonia, and added than 20,000 tonnes per year are bogus worldwide.
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CAS No.: 24016-03-3
Molecular Formula: C12H12N2O
Molecular Weight: 200.2
Appearance white to yellowish crystal
Purity (%) 99.0 min.
Moisture (%) 0.5 max.
Melting point (°C) 95 - 98 (melting range less than 2)
Pyridineis a basal heterocyclic amoebic admixture with the actinic blueprint C5H5N. It is structurally accompanying to benzene, with one C-H accumulation replaced by a nitrogen atom. The pyridine ring occurs in abounding important compounds, including azines and the vitamins niacin and pyridoxal.
Pyridine was apparent in 1849 by the Scottish chemist Thomas Anderson as one of the capacity of cartilage oil. Two years later, Anderson abandoned authentic pyridine through apportioned beverage of the oil. It is a colorless, awful flammable, abominably alkaline, water-soluble aqueous with a distinctive, abhorrent fish-like odor.
Pyridine is acclimated as a forerunner to agrochemicals and pharmaceuticals and is aswell an important bread-and-butter and reagent. Pyridine is added to booze to accomplish it clashing for drinking. It is acclimated in the in vitro amalgam of DNA, in the amalgam of sulfapyridine (a biologic adjoin bacterial and viral infections), antihistaminic drugs tripelennamine and mepyramine, as able-bodied as baptize repellents, bactericides and herbicides. Some actinic compounds, although not actinic from pyridine, accommodate its ring structure. They cover B vitamins niacin and pyridoxal, an anti-tuberculosis biologic isoniazid, nicotine and added nitrogen-containing bulb products.
Historically, pyridine was produced from atramentous tar and as a by-product of the atramentous gasification. However, added appeal for pyridine resulted in the development of added economical methods of amalgam from acetaldehyde and ammonia, and added than 20,000 tonnes per year are bogus worldwide.
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Thursday, April 12, 2012
Where to find 2-[(Tribromomethyl)sulfonyl]-pyridine?
2-[(Tribromomethyl)sulfonyl]-pyridine
CAS Registry Number: 59626-33-4
Formula: C6H4Br3NO2S
Molecular Weight: 393.88
Appearance White crystal
Purity (%) 99 min.
Loss on drying (%) 0.5 max.
Melting point (ºC) 159 - 162
Sulfapyridine, aboriginal UK spelling sulphapyridine, is a sulfonamide antibacterial. At one time it was frequently referred to as M&B.
Sulfapyridine is not assigned for analysis in bodies any more. However, it may be acclimated to amusement Linear IgA Disease. It is a acceptable antibacterial drug, but its baptize solubility is actual pH dependent. Thus there is a accident of condensate aural the float or urethra, which could advance to affliction or blockage.
Discovered by May & Baker Ltd and logged in their Test Book on 2 November 1937 beneath Code No M&B693. Successfully acclimated to amusement Winston Churchill's bacterial pneumonia in 1942. In a consecutive radio advertisement he said "This admirable M&B from which I did not ache any inconvenience, was acclimated at the ancient moment and, afterwards a week's fever, the intruders were repulsed." In 1944 M&B693 aswell adored Nero, the Royal Circus lion, from pneumonia.
The biologic sulfasalazine is structurally one atom of mesalamine affiliated to one atom of Sulfapyridine with an azo bond.
A sulfonyl accumulation can accredit either to a anatomic accumulation begin primarily in sulfones or to a substituent acquired from a sulfonic acerbic by the abatement of the hydroxyl accumulation analogously to acyl groups. Sulfonyl groups can be accounting as accepting the accepted blueprint R-S(=O)2-R', area there are two bifold bonds amid the sulfur and oxygen.
Sulfonyl groups can be bargain to the hydrocarbon with lithium aluminium hydride (LiAlH4).
In asleep chemistry, if the accumulation -S(=O)2- is not affiliated to any carbon atoms, it is referred to as sulfuryl.
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CAS Registry Number: 59626-33-4
Formula: C6H4Br3NO2S
Molecular Weight: 393.88
Appearance White crystal
Purity (%) 99 min.
Loss on drying (%) 0.5 max.
Melting point (ºC) 159 - 162
Sulfapyridine, aboriginal UK spelling sulphapyridine, is a sulfonamide antibacterial. At one time it was frequently referred to as M&B.
Sulfapyridine is not assigned for analysis in bodies any more. However, it may be acclimated to amusement Linear IgA Disease. It is a acceptable antibacterial drug, but its baptize solubility is actual pH dependent. Thus there is a accident of condensate aural the float or urethra, which could advance to affliction or blockage.
Discovered by May & Baker Ltd and logged in their Test Book on 2 November 1937 beneath Code No M&B693. Successfully acclimated to amusement Winston Churchill's bacterial pneumonia in 1942. In a consecutive radio advertisement he said "This admirable M&B from which I did not ache any inconvenience, was acclimated at the ancient moment and, afterwards a week's fever, the intruders were repulsed." In 1944 M&B693 aswell adored Nero, the Royal Circus lion, from pneumonia.
The biologic sulfasalazine is structurally one atom of mesalamine affiliated to one atom of Sulfapyridine with an azo bond.
A sulfonyl accumulation can accredit either to a anatomic accumulation begin primarily in sulfones or to a substituent acquired from a sulfonic acerbic by the abatement of the hydroxyl accumulation analogously to acyl groups. Sulfonyl groups can be accounting as accepting the accepted blueprint R-S(=O)2-R', area there are two bifold bonds amid the sulfur and oxygen.
Sulfonyl groups can be bargain to the hydrocarbon with lithium aluminium hydride (LiAlH4).
In asleep chemistry, if the accumulation -S(=O)2- is not affiliated to any carbon atoms, it is referred to as sulfuryl.
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Friday, April 6, 2012
What is Warfarin metabolite 3?
Warfarin metabolite 3
Systematic name: 2H-Pyran-3(4H)-one, dihydro-6-hydroxy-6-methyl-2-(2-oxo-3,5-cyclohexadien-1-ylidene)-4-phenyl-
Molecular formulae: C18H16O4
Molecular weight: 296
CAS:119465-35-9
Description of Warfarin metabolite 3
Control of rats and mice. Commercial baits are usually in a concentration of 0.02% warfarin. They may be formulated as corn-meal or oats, or other grains. There is no tendency to bait shyness. Warfarin is no longer popular as a rodenticide because rats and mice have become resistant (Tomlin, 1994).
It is available as the sodium salt of the racemic mixture for use as an anticoagulant, in oral doses of 2 to 25 mg daily.
Uses
Anticoagulant rodenticide.
Therapeutic anticoagulant.
Warfarin metabolites are less bound both within plasma and a 40 g/liter solution of human serum albumin than the enantiomers of warfarin. The reduced warfarin metabolites have a lower fraction unbound [1.33% for (S,R)-WA, 2.09% for (S,S)-WA, and 1.04% for (R,S)-WA] than hydroxylated metabolites [3.24% for (R)-6-HW, 4.26% (S)-6-HW, 4.49% for (R)-7-HW and 4.27% for (S)-7-HW] to HSA. Phenylbutazone produced a concentration-dependent increase in the unbound fraction of all metabolites. It was possible to predict the unbound fraction of warfarin metabolites based on the unbound fraction of warfarin enantiomers. © 1993 Wiley-Liss, Inc.
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Systematic name: 2H-Pyran-3(4H)-one, dihydro-6-hydroxy-6-methyl-2-(2-oxo-3,5-cyclohexadien-1-ylidene)-4-phenyl-
Molecular formulae: C18H16O4
Molecular weight: 296
CAS:119465-35-9
Description of Warfarin metabolite 3
Control of rats and mice. Commercial baits are usually in a concentration of 0.02% warfarin. They may be formulated as corn-meal or oats, or other grains. There is no tendency to bait shyness. Warfarin is no longer popular as a rodenticide because rats and mice have become resistant (Tomlin, 1994).
It is available as the sodium salt of the racemic mixture for use as an anticoagulant, in oral doses of 2 to 25 mg daily.
Uses
Anticoagulant rodenticide.
Therapeutic anticoagulant.
Warfarin metabolites are less bound both within plasma and a 40 g/liter solution of human serum albumin than the enantiomers of warfarin. The reduced warfarin metabolites have a lower fraction unbound [1.33% for (S,R)-WA, 2.09% for (S,S)-WA, and 1.04% for (R,S)-WA] than hydroxylated metabolites [3.24% for (R)-6-HW, 4.26% (S)-6-HW, 4.49% for (R)-7-HW and 4.27% for (S)-7-HW] to HSA. Phenylbutazone produced a concentration-dependent increase in the unbound fraction of all metabolites. It was possible to predict the unbound fraction of warfarin metabolites based on the unbound fraction of warfarin enantiomers. © 1993 Wiley-Liss, Inc.
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Monday, April 2, 2012
Applications of Methanesulfonyl chloride
Methanesulfonyl chloride is a compound containing a sulfonyl chloride used to make methanesulfonates and to generate sulfene.
Methanesulfonyl chloride is awful toxic, damp sensitive, corrosive, and a lachrymator. It should be stored in a dry location, finer in a desiccator. It is bogus either via absolute admixture from methane and sulfuryl chloride in a abolitionist reaction.
other adjustment of accomplish starts with methanesulfonic acid, which is attainable out of methane and sulfur trioxide or by active blaze of methanethiol
The methanesulfonic acerbic able is reacted with thionyl chloride or phosgene to anatomy mesyl chloride
Applications
Methanesulfonates
The capital use of Methanesulfonyl chloride is the accumulation of methanesulfonates from alcohols in the attendance of a non-nucleophilic base. Methanesulfonates are acclimated as intermediates in barter reactions, abolishment reactions, reductions, and barter reactions. When advised with a Lewis acid, oxime methanesulfonates will abide a accomplished Beckmann rearrangement.
Methanesulfonates accept been occasionally acclimated as a attention accumulation for alcohols. It is abiding to acerb altitude and is broken aback to the booze application sodium amalgam.
Methanesulfonamides
Methanesulfonyl chloride will acknowledge with amines to anatomy a methanesulfonamide. Unlike a methanesulfonate, a methanesulfonamide is a actual abiding anatomic accumulation beneath both acerb and basal conditions. When acclimated as a attention group, they can be adapted aback to amines application lithium aluminium hydride or a abandoning metal reduction.
Addition to alkynes
In the attendance of copper(II) chloride, methanesulfonyl chloride will add beyond alkynes to anatomy β-chloro sulfones.
Accumulation of heterocycles
Upon analysis with a base, such as triethylamine, methanesulfonyl chloride will abide an abolishment to anatomy sulfene. Sulfene can abide cycloadditions to anatomy assorted heterocycles. α-Hydroxyketones acknowledge with sulfene to anatomy five-membered sultones.
Miscellaneous
Forming acyliminium ions from α-hydroxyamides can be done application methanesulfonyl chloride and a base, about triethylamine.
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Methanesulfonyl chloride is awful toxic, damp sensitive, corrosive, and a lachrymator. It should be stored in a dry location, finer in a desiccator. It is bogus either via absolute admixture from methane and sulfuryl chloride in a abolitionist reaction.
other adjustment of accomplish starts with methanesulfonic acid, which is attainable out of methane and sulfur trioxide or by active blaze of methanethiol
The methanesulfonic acerbic able is reacted with thionyl chloride or phosgene to anatomy mesyl chloride
Applications
Methanesulfonates
The capital use of Methanesulfonyl chloride is the accumulation of methanesulfonates from alcohols in the attendance of a non-nucleophilic base. Methanesulfonates are acclimated as intermediates in barter reactions, abolishment reactions, reductions, and barter reactions. When advised with a Lewis acid, oxime methanesulfonates will abide a accomplished Beckmann rearrangement.
Methanesulfonates accept been occasionally acclimated as a attention accumulation for alcohols. It is abiding to acerb altitude and is broken aback to the booze application sodium amalgam.
Methanesulfonamides
Methanesulfonyl chloride will acknowledge with amines to anatomy a methanesulfonamide. Unlike a methanesulfonate, a methanesulfonamide is a actual abiding anatomic accumulation beneath both acerb and basal conditions. When acclimated as a attention group, they can be adapted aback to amines application lithium aluminium hydride or a abandoning metal reduction.
Addition to alkynes
In the attendance of copper(II) chloride, methanesulfonyl chloride will add beyond alkynes to anatomy β-chloro sulfones.
Accumulation of heterocycles
Upon analysis with a base, such as triethylamine, methanesulfonyl chloride will abide an abolishment to anatomy sulfene. Sulfene can abide cycloadditions to anatomy assorted heterocycles. α-Hydroxyketones acknowledge with sulfene to anatomy five-membered sultones.
Miscellaneous
Forming acyliminium ions from α-hydroxyamides can be done application methanesulfonyl chloride and a base, about triethylamine.
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Saturday, March 31, 2012
Specifications of Fumonisin B2
Fumonisin B2
CAS Number: 116355-84-1
Molecular Weight: 705.8
Molecular Formula: C34H59NO14
Purity: ≥98%
Physical Appearance: White solid
Solubility: Soluble in water (25 mg/ml)
Description
Fumonisin B2 is a fumonisin mycotoxin produced by the fungi Fusarium verticillioides and Fusarium moniliforme.[1] It is a structural analog of fumonisin B1. Fumonisin B2 is added cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase.
Fumonisin B2 and added fumonisins frequently alloy maize and added crops.
Structural analog of fumonisin B1(cat no.sc-201395 and sc-201395A). Fumonisin B2 is added cytotoxic than fumonisin B1 and inhibits sphingosine acyltransferase. Fumonisin B2 and added fumonisins frequently alloy maize and added crops. A fungal metabolite produced by Fusarium moniliforme. It inhibits sphingolipid biosynthesis via inhibition of sphinganine N-acyltransferase. IC50=0.1 µM in rat alarmist microsomes.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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CAS Number: 116355-84-1
Molecular Weight: 705.8
Molecular Formula: C34H59NO14
Purity: ≥98%
Physical Appearance: White solid
Solubility: Soluble in water (25 mg/ml)
Description
Fumonisin B2 is a fumonisin mycotoxin produced by the fungi Fusarium verticillioides and Fusarium moniliforme.[1] It is a structural analog of fumonisin B1. Fumonisin B2 is added cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase.
Fumonisin B2 and added fumonisins frequently alloy maize and added crops.
Structural analog of fumonisin B1(cat no.sc-201395 and sc-201395A). Fumonisin B2 is added cytotoxic than fumonisin B1 and inhibits sphingosine acyltransferase. Fumonisin B2 and added fumonisins frequently alloy maize and added crops. A fungal metabolite produced by Fusarium moniliforme. It inhibits sphingolipid biosynthesis via inhibition of sphinganine N-acyltransferase. IC50=0.1 µM in rat alarmist microsomes.
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Thursday, March 29, 2012
Differences between Stannous methanesulfonate and Ethyl methanesulfonate
Stannous methanesulfonate
Synonyms: Methanesulfonic acid tin(2+) salt; Tin(II) methanesulfonate
CAS Registry Number: 53408-94-9
Formula: Sn(CH3O3S)2
Molecular Weight: 310.89
Tin(II) sulfate (SnSO4) is a actinic compound. It is a white solid that can blot abundant damp from the air to deliquesce in it, basic a solution; this acreage is accepted as deliquescence. It can be able by a displacement acknowledgment amid brownish tin and copper(II) sulfate. Tin(II) sulfate is a acceptable antecedent of tin(II) ions austere by tin(IV) species.
Character: transparent liquid of no color or light yellowish, easy to be oxidation to color yellow. The specific gravity is 1.53.
Usage: mainly being material of electric-plating and electric industry.
Ethyl methanesulfonate (EMS) is a mutagenic, teratogenic, and possibly baleful amoebic admixture with blueprint CH3SO3C2H5. It produces accidental mutations in abiogenetic actual by nucleotide substitution; decidedly by guanine alkylation. This about produces alone point mutations. It can abet mutations at a amount of 5x10-4 to 5x10-2 per gene after abundant killing. The ethyl accumulation of EMS reacts with guanine in DNA, basic the aberrant abject O-6-ethylguanine. During DNA replication, DNA polymerases that activate the action frequently abode thymine, instead of cytosine, adverse O-6-ethylguanine. Following consecutive circuit of replication, the aboriginal G:C abject brace can become an A:T pair. This changes the abiogenetic information, is generally adverse to cells, and can aftereffect in disease.
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Synonyms: Methanesulfonic acid tin(2+) salt; Tin(II) methanesulfonate
CAS Registry Number: 53408-94-9
Formula: Sn(CH3O3S)2
Molecular Weight: 310.89
Tin(II) sulfate (SnSO4) is a actinic compound. It is a white solid that can blot abundant damp from the air to deliquesce in it, basic a solution; this acreage is accepted as deliquescence. It can be able by a displacement acknowledgment amid brownish tin and copper(II) sulfate. Tin(II) sulfate is a acceptable antecedent of tin(II) ions austere by tin(IV) species.
Character: transparent liquid of no color or light yellowish, easy to be oxidation to color yellow. The specific gravity is 1.53.
Usage: mainly being material of electric-plating and electric industry.
Ethyl methanesulfonate (EMS) is a mutagenic, teratogenic, and possibly baleful amoebic admixture with blueprint CH3SO3C2H5. It produces accidental mutations in abiogenetic actual by nucleotide substitution; decidedly by guanine alkylation. This about produces alone point mutations. It can abet mutations at a amount of 5x10-4 to 5x10-2 per gene after abundant killing. The ethyl accumulation of EMS reacts with guanine in DNA, basic the aberrant abject O-6-ethylguanine. During DNA replication, DNA polymerases that activate the action frequently abode thymine, instead of cytosine, adverse O-6-ethylguanine. Following consecutive circuit of replication, the aboriginal G:C abject brace can become an A:T pair. This changes the abiogenetic information, is generally adverse to cells, and can aftereffect in disease.
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Wednesday, March 28, 2012
What is Xanthoascin (1)?
Xanthoascin (1)
Systematic name: Phenol, 4-[4-(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,3-diisocyano-1,3-butadienyl]-
Molecular formulae: C23H20N2O2
Molecular weight: 356
CAS:61391-08-0
Xanthoascin, a baneful metabolite afresh abandoned from rice grains infested with Aspergillus candidus L., acquired astute hepatic abrasion with jaundice in mice. It can be a applicant as a adroit abettor of primary myocardial diseases of men and contagion of foods with A. candidus and xanthoascin should be eargently examined.Xanthoascins accept alone been begin in A. candidus.
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Systematic name: Phenol, 4-[4-(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)-2,3-diisocyano-1,3-butadienyl]-
Molecular formulae: C23H20N2O2
Molecular weight: 356
CAS:61391-08-0
Xanthoascin, a baneful metabolite afresh abandoned from rice grains infested with Aspergillus candidus L., acquired astute hepatic abrasion with jaundice in mice. It can be a applicant as a adroit abettor of primary myocardial diseases of men and contagion of foods with A. candidus and xanthoascin should be eargently examined.Xanthoascins accept alone been begin in A. candidus.
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Tuesday, March 27, 2012
Specifications of Methanesulfonyl anhydride
Methanesulfonyl anhydride
Synonyms: Mesyl anhydride; Methanesulfonic acid anhydride
CAS Registry Number: [ 7143-01-3 ]
Formula: C2H6O5S2
Molecular Weight: 174.20
Description
Appearance Light grey crystal
Purity (%) 99.0 min.
Methanesulfonyl chloride (%) 1.0 max.
Iron (ppm) 10 max.
Heavy metals (ppm) 10 max.
Methanesulfonyl anhydride is an is the acid anhydride of methanesulfonic acid. Like methanesulfonyl chloride, it may be used to generate mesylates (methanesulfonyl esters).
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Synonyms: Mesyl anhydride; Methanesulfonic acid anhydride
CAS Registry Number: [ 7143-01-3 ]
Formula: C2H6O5S2
Molecular Weight: 174.20
Description
Appearance Light grey crystal
Purity (%) 99.0 min.
Methanesulfonyl chloride (%) 1.0 max.
Iron (ppm) 10 max.
Heavy metals (ppm) 10 max.
Methanesulfonyl anhydride is an is the acid anhydride of methanesulfonic acid. Like methanesulfonyl chloride, it may be used to generate mesylates (methanesulfonyl esters).
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Sunday, March 25, 2012
What is 2,3-Dihydroxypyridine?
2,3-Dihydroxypyridine
Synonyms: 2,3-Pyridinediol
CAS Registry Number: 16867-04-2
Formula: C5H5NO2
Molecular Weight: 111.1
2,3-Dihydroxypyridine is brown crystalline powder with Purity of 99.0 % min. Moisture is 0.5%max. Melting point is 245ºC- 248ºC(melting range less than 2)
2,3-Dihydroxypyridine is used as pharmaceutical intermediate.
2,6-Dihydroxypyridine is an alkaloid with the molecular formula C5H3N(OH)2. It is a colorless solid. 2,6-Dihyroxypyridine is an intermediate in the degradation of nicotine. 2,6-Dihydroxypyridine has been investigated in an oxidation method of dyeing hair. The process utilizes 2,6-dihydroxypyridine as a coupling agent, and 2,4,5,6-tetraaminopyrimidine as a primary intermediate. This oxidation method intensifies the color of the dyed hair for several days.
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Synonyms: 2,3-Pyridinediol
CAS Registry Number: 16867-04-2
Formula: C5H5NO2
Molecular Weight: 111.1
2,3-Dihydroxypyridine is brown crystalline powder with Purity of 99.0 % min. Moisture is 0.5%max. Melting point is 245ºC- 248ºC(melting range less than 2)
2,3-Dihydroxypyridine is used as pharmaceutical intermediate.
2,6-Dihydroxypyridine is an alkaloid with the molecular formula C5H3N(OH)2. It is a colorless solid. 2,6-Dihyroxypyridine is an intermediate in the degradation of nicotine. 2,6-Dihydroxypyridine has been investigated in an oxidation method of dyeing hair. The process utilizes 2,6-dihydroxypyridine as a coupling agent, and 2,4,5,6-tetraaminopyrimidine as a primary intermediate. This oxidation method intensifies the color of the dyed hair for several days.
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Thursday, March 22, 2012
Specifications of 2-Chloro-3-cyanopyridine
2-Chloro-3-cyanopyridine
Synonyms 2-Chloronicotinonitrile; 3-Cyano-2-chloropyridine
Molecular Formula C6H3ClN2
Molecular Weight 138.56
CAS Registry Number 6602-54-6
Description of 2-Chloro-3-cyanopyridine
Appearance: White to slight yellow crystalline powder
Storage : Preserve in tight dry ray-resistant containers
Purity (%) 99.0 min.
Moisture (%) 0.5 max.
Melting point (°C) 105 - 108 (melting range less than 2)
2-Chloro-3-cyanopyridine is used for pharmaceutical intermediate and packed in 25 kg net in carton drum.
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Synonyms 2-Chloronicotinonitrile; 3-Cyano-2-chloropyridine
Molecular Formula C6H3ClN2
Molecular Weight 138.56
CAS Registry Number 6602-54-6
Description of 2-Chloro-3-cyanopyridine
Appearance: White to slight yellow crystalline powder
Storage : Preserve in tight dry ray-resistant containers
Purity (%) 99.0 min.
Moisture (%) 0.5 max.
Melting point (°C) 105 - 108 (melting range less than 2)
2-Chloro-3-cyanopyridine is used for pharmaceutical intermediate and packed in 25 kg net in carton drum.
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What is Phloroglucinol used for?
Phloroglucinol is a benzenetriol. It is an organic compound that is used in the synthesis of pharmaceuticals and explosives. This molecule exists in two forms, or tautomers, 1,3,5-trihydroxybenzene, which has phenol-like, and 1,3,5-cyclohexanetrione (phloroglucin), which has ketone-like character. These two tautomers are in equilibrium. Phloroglucinol is a useful intermediate because it is polyfunctional.
Phloroglucinols occur naturally in certain plant species. For example, they (and sometimes their acyl dervatives) are present in the fronds of the coastal woodfern, Dryopteris arguta. Brown algae also produce phloroglucinol derivatives known as phlorotannins.
Applications
Phloroglucinol is mainly used as a coupling agent in printing. It links diazo dyes to give a fast black.
It is useful for the industrial synthesis of pharmaceuticals and explosives. It is also used as a treatment for gallstones, spasmodic pain and other related gastrointestinal disorders. It has a non-specific spasmolytic action on the vessels, bronchi, intestine, ureters and gall bladder, and is used for treating disorders of these organs.
Phloroglucinolysis is an analytical technique to study condensed tannins by mean of depolymerisation. The reaction makes use of phloroglucinol as nucleophile.
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Phloroglucinols occur naturally in certain plant species. For example, they (and sometimes their acyl dervatives) are present in the fronds of the coastal woodfern, Dryopteris arguta. Brown algae also produce phloroglucinol derivatives known as phlorotannins.
Applications
Phloroglucinol is mainly used as a coupling agent in printing. It links diazo dyes to give a fast black.
It is useful for the industrial synthesis of pharmaceuticals and explosives. It is also used as a treatment for gallstones, spasmodic pain and other related gastrointestinal disorders. It has a non-specific spasmolytic action on the vessels, bronchi, intestine, ureters and gall bladder, and is used for treating disorders of these organs.
Phloroglucinolysis is an analytical technique to study condensed tannins by mean of depolymerisation. The reaction makes use of phloroglucinol as nucleophile.
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Wednesday, March 21, 2012
What is Regatin A?
Regatin A
Systematic name:3(2H)-Furanone, 2-(1E,3E)-1,3-hexadienyl-5-methoxy-2-methyl-4-[(2E)-1-oxo-2-butenyl]-, (-)-
Molecular formulae:C16H20O4
Molecular weight:276
Cas number: 65794-79-8
Regatin A (Fig. 1A) which is produced by Phialophora gregata (Allington and Chamberlain) W. Gams, is an enantiomer of aspertetronin A (Fig. 1B), which is a accepted metabolite from cultures of Aspergillus rugulosus.
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Systematic name:3(2H)-Furanone, 2-(1E,3E)-1,3-hexadienyl-5-methoxy-2-methyl-4-[(2E)-1-oxo-2-butenyl]-, (-)-
Molecular formulae:C16H20O4
Molecular weight:276
Cas number: 65794-79-8
Regatin A (Fig. 1A) which is produced by Phialophora gregata (Allington and Chamberlain) W. Gams, is an enantiomer of aspertetronin A (Fig. 1B), which is a accepted metabolite from cultures of Aspergillus rugulosus.
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Descriptions of Antimicrobial Metabolite 1
Description of Antimicrobial Metabolite 1
Absolute configuration of keisslone, a new antimicrobial metabolite from Keissleriella sp. YS4108, a marine filamentous fungus.
Cas number:89367-83-9
Formula: C15H10O5
An antimicrobial is a substance that kills or inhibits the growth of microorganisms such as bacteria, fungi, or protozoans. Antimicrobial drugs either kill microbes (microbiocidal) or prevent the growth of microbes (microbiostatic). Disinfectants are antimicrobial substances used on non-living objects or outside the body.
The antimicrobial properties of 21 plant essential oils and two essences were investigated against five food-borne pathogens, Campylobacter jejuni, Salmonella enteriditis, Escherichia coli, Staphylococus aureus and Listeria monocytogenes. The oils of bay, cinnamon, clove and thyme were the most inhibitory, each having a bacteriostatic concentration of 0.075% or less against all five pathogens.
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Absolute configuration of keisslone, a new antimicrobial metabolite from Keissleriella sp. YS4108, a marine filamentous fungus.
Cas number:89367-83-9
Formula: C15H10O5
An antimicrobial is a substance that kills or inhibits the growth of microorganisms such as bacteria, fungi, or protozoans. Antimicrobial drugs either kill microbes (microbiocidal) or prevent the growth of microbes (microbiostatic). Disinfectants are antimicrobial substances used on non-living objects or outside the body.
The antimicrobial properties of 21 plant essential oils and two essences were investigated against five food-borne pathogens, Campylobacter jejuni, Salmonella enteriditis, Escherichia coli, Staphylococus aureus and Listeria monocytogenes. The oils of bay, cinnamon, clove and thyme were the most inhibitory, each having a bacteriostatic concentration of 0.075% or less against all five pathogens.
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Tuesday, March 20, 2012
Applications of 4-Aminopyridine
4-Aminopyridine (INN fampridine, USAN dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used primarily as a research tool, in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. The drug has orphan drug status in the United States under the trade name Neurelan. It was undergoing Phase III clinical trials as of 2008, and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010. Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and as Fampyra in Europe.
Applications
The largest scale industrial application of 4-Aminopyridine is as a precursor to the drug pinacidil, which affects potassium ion channels.
In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. It is a relatively selective blocker of members of Kv1 (Shaker, KCNA) family of voltage-activated K+ channels. At concentration of 1 mM it selectively and reversibly inhibits Shaker channels without significant effect on other sodium, calcium, and potassium conductances.
4-Aminopyridine is also used as a bird control agent, under the trade name Avitrol; it causes convulsions and typically death, depending on dosage. The use of 4-aminopyridine in bird control has been criticized by the Humane Society of the United States.
Medical use
Fampridine has been used clinically in Lambert-Eaton myasthenic syndrome and multiple sclerosis. It acts by blocking potassium channels, prolonging action potentials and thereby increasing neurotransmitter release at the neuromuscular junction. The drug has been shown to reverse tetrodotoxin toxicity in animal experiments.
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Applications
The largest scale industrial application of 4-Aminopyridine is as a precursor to the drug pinacidil, which affects potassium ion channels.
In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. It is a relatively selective blocker of members of Kv1 (Shaker, KCNA) family of voltage-activated K+ channels. At concentration of 1 mM it selectively and reversibly inhibits Shaker channels without significant effect on other sodium, calcium, and potassium conductances.
4-Aminopyridine is also used as a bird control agent, under the trade name Avitrol; it causes convulsions and typically death, depending on dosage. The use of 4-aminopyridine in bird control has been criticized by the Humane Society of the United States.
Medical use
Fampridine has been used clinically in Lambert-Eaton myasthenic syndrome and multiple sclerosis. It acts by blocking potassium channels, prolonging action potentials and thereby increasing neurotransmitter release at the neuromuscular junction. The drug has been shown to reverse tetrodotoxin toxicity in animal experiments.
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How to get Diphenolic acid?
Diphenolic acid
Synonyms: 4,4-Bis(4-hydroxyphenyl)pentanoic acid; 4,4'-Bis(4-hydroxyphenyl)valeric acid; CTFA
CAS Registry Number: 126-00-1
Formula: C17H18O4
Molecular Weight: 286.32
Diphenolic acerbic is a carboxylic acerbic with atomic blueprint C17H18O4. Its IUPAC name is 4,4-bis(p-hydroxyphenyl)pentanoic acid, and it can be able by the abstract acknowledgment of phenol with levulinic acerbic in the attendance of hydrochloric acid.
Diphenolic acid is a solid at room temperature, melting at 168–171 °C and boiling at 507 °C. According to its MSDS, diphenolic acid is soluble in ethanol, isopropanol, acetone, acetic acid, and methyl ethyl ketone, but insoluble in benzene, carbon tetrachloride, and xylene.
Diphenolic acid may be a suitable replacement for bisphenol A as a plasticizer.
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Monday, March 19, 2012
What is Warfarin metabolite 2?
Warfarin metabolite 2
Systematic name 2,5-Hexanedione, 1-hydroxy-1-(2-oxo-3,5-cyclohexadien-1-ylidene)-3-phenyl-, (E)-
Molecular formulae: C18H16O4
Molecular weight: 296
CAS:119465-34-8
Warfarin metabolites,Stereochemical aspects of protein binding and displacement by phenylbutazone.Warfarin metabolism may be inhibited through drug-drug interactions, including amiodarone and statins.
Warfarin is an oral anticoagulant that inhibits the synthesis of clotting factors, thus preventing blood clot formation. Blood clots can occur in the veins of the lower extremities, usually after periods of immobility. These clots can break off and become lodged in the blood vessels of the lung (pulmonary embolism), causing shortness of breath, chest pain, and even life-threatening shock. Blood clots can also occur in the atria of the heart during atrial fibrillation, and around artificial heart valves. One of these clots can also break off and obstruct a blood vessel in the brain, causing an embolic stroke with paralysis. Coumadin is important in preventing the formation of blood clots. It is also important to prevent extension of clots already formed, and to minimize the risk of blood clot embolization to other vital organs such as the lungs and brain.
Warfarin is used in treating patients with blood clots in the lower extremities to prevent extension of the clot, and to reduce the risk of pulmonary embolism. Patients with pulmonary embolism are treated with Coumadin to prevent further blood clot emboli. Coumadin is also used in patients with atrial fibrillation and artificial heart valves to reduce the risk of strokes. It is also helpful in preventing blood clot formation in certain orthopedic surgeries such as knee or hip replacements. Coumadin is also used in preventing blood clot closure of coronary artery stents.
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Systematic name 2,5-Hexanedione, 1-hydroxy-1-(2-oxo-3,5-cyclohexadien-1-ylidene)-3-phenyl-, (E)-
Molecular formulae: C18H16O4
Molecular weight: 296
CAS:119465-34-8
Warfarin metabolites,Stereochemical aspects of protein binding and displacement by phenylbutazone.Warfarin metabolism may be inhibited through drug-drug interactions, including amiodarone and statins.
Warfarin is an oral anticoagulant that inhibits the synthesis of clotting factors, thus preventing blood clot formation. Blood clots can occur in the veins of the lower extremities, usually after periods of immobility. These clots can break off and become lodged in the blood vessels of the lung (pulmonary embolism), causing shortness of breath, chest pain, and even life-threatening shock. Blood clots can also occur in the atria of the heart during atrial fibrillation, and around artificial heart valves. One of these clots can also break off and obstruct a blood vessel in the brain, causing an embolic stroke with paralysis. Coumadin is important in preventing the formation of blood clots. It is also important to prevent extension of clots already formed, and to minimize the risk of blood clot embolization to other vital organs such as the lungs and brain.
Warfarin is used in treating patients with blood clots in the lower extremities to prevent extension of the clot, and to reduce the risk of pulmonary embolism. Patients with pulmonary embolism are treated with Coumadin to prevent further blood clot emboli. Coumadin is also used in patients with atrial fibrillation and artificial heart valves to reduce the risk of strokes. It is also helpful in preventing blood clot formation in certain orthopedic surgeries such as knee or hip replacements. Coumadin is also used in preventing blood clot closure of coronary artery stents.
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Sunday, March 18, 2012
Specifications of 3-Hydroxypyridine
3-Hydroxypyridine
CAS No.: 109-00-2
Formula: C5H5NO
Molecular Weight: 95.1
3-Hydroxypyridine is also called 3-Pyridinol, 3-Hydroxypyridine is yellow to brownish crystal. Its Purity is 99.0% min. Moisture is 0.5% max. Sulfate ash is 0.5% max. Melting point of 3-Hydroxypyridine is 124°C - 127 °C.
3-Hydroxypyridine is used as pharmaceutical intermediate and packed in 25 kg net in carton drum.
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CAS No.: 109-00-2
Formula: C5H5NO
Molecular Weight: 95.1
3-Hydroxypyridine is also called 3-Pyridinol, 3-Hydroxypyridine is yellow to brownish crystal. Its Purity is 99.0% min. Moisture is 0.5% max. Sulfate ash is 0.5% max. Melting point of 3-Hydroxypyridine is 124°C - 127 °C.
3-Hydroxypyridine is used as pharmaceutical intermediate and packed in 25 kg net in carton drum.
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Thursday, March 15, 2012
Properties of Silica gel
Silica gel
is a granular, vitreous, absorptive anatomy of silicon dioxide fabricated synthetically from sodium silicate. Despite its name, silica gel is a solid. It is a by itself occurring mineral that is antiseptic and candy into either diminutive or beaded form. As a desiccant, it has an boilerplate pore admeasurement of 2.4 nanometers and has a able affection for baptize molecules.
Silica gel is a lot of frequently encountered in accustomed activity as chaplet in a baby (typically 2 cm x 3 cm) cardboard packet. In this form, it is acclimated as a anhydrous to ascendancy bounded clamminess in adjustment to abstain accident or abasement of some goods. Because of poisonous dopants (see below) and their actual top assimilation of moisture, silica gel packets usually buck warnings for the user not to eat the contents.
Properties
Silica gel's top apparent breadth (around 800 m²/g) allows it to blot baptize readily, authoritative it advantageous as a anhydrous (drying agent). Once saturated with water, the gel can be regenerated by heating it to 120 °C (250 °F) for two hours. Some types of silica gel will "pop" if apparent to abundant water. This is acquired by accident of the silica spheres if contacting the water.
Uses
Silica gel may aswell be acclimated to accumulate the about clamminess (RH) central a top abundance radio or digital manual arrangement waveguide as low as accessible (see aswell Clamminess buffering). Excessive damp accretion aural a waveguide can could cause arcing central the waveguide itself, damaging the ability amplifier agriculture it. Also, the chaplet of baptize that anatomy and abbreviate central the waveguide change the appropriate impedance and frequency, aspersing the signal. It is accepted for a baby aeroembolism air arrangement (similar to a baby home aquarium pump) to be active to broadcast the air central the waveguide over a jar of silica gel.
Silica gel is aswell acclimated to dry the air in automated aeroembolism air systems. Air from the compressor acquittal flows through a bed of silica gel beads. The silica gel absorbs damp from the air, preventing accident at the point of use of the aeroembolism air due to abstract or moisture. The aforementioned arrangement is acclimated to dry the aeroembolism air on railway locomotives, area abstract and ice in the anchor air pipes can advance to anchor failure.
Silica gel is sometimes acclimated as a canning apparatus to ascendancy about clamminess in building and library exhibitions and storage.
Other applications cover analytic analysis strips, assimilation devices, syringes, biologic analysis kits and hospital sanitation kits.More about: Silica gel sale
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is a granular, vitreous, absorptive anatomy of silicon dioxide fabricated synthetically from sodium silicate. Despite its name, silica gel is a solid. It is a by itself occurring mineral that is antiseptic and candy into either diminutive or beaded form. As a desiccant, it has an boilerplate pore admeasurement of 2.4 nanometers and has a able affection for baptize molecules.
Silica gel is a lot of frequently encountered in accustomed activity as chaplet in a baby (typically 2 cm x 3 cm) cardboard packet. In this form, it is acclimated as a anhydrous to ascendancy bounded clamminess in adjustment to abstain accident or abasement of some goods. Because of poisonous dopants (see below) and their actual top assimilation of moisture, silica gel packets usually buck warnings for the user not to eat the contents.
Properties
Silica gel's top apparent breadth (around 800 m²/g) allows it to blot baptize readily, authoritative it advantageous as a anhydrous (drying agent). Once saturated with water, the gel can be regenerated by heating it to 120 °C (250 °F) for two hours. Some types of silica gel will "pop" if apparent to abundant water. This is acquired by accident of the silica spheres if contacting the water.
Uses
Silica gel may aswell be acclimated to accumulate the about clamminess (RH) central a top abundance radio or digital manual arrangement waveguide as low as accessible (see aswell Clamminess buffering). Excessive damp accretion aural a waveguide can could cause arcing central the waveguide itself, damaging the ability amplifier agriculture it. Also, the chaplet of baptize that anatomy and abbreviate central the waveguide change the appropriate impedance and frequency, aspersing the signal. It is accepted for a baby aeroembolism air arrangement (similar to a baby home aquarium pump) to be active to broadcast the air central the waveguide over a jar of silica gel.
Silica gel is aswell acclimated to dry the air in automated aeroembolism air systems. Air from the compressor acquittal flows through a bed of silica gel beads. The silica gel absorbs damp from the air, preventing accident at the point of use of the aeroembolism air due to abstract or moisture. The aforementioned arrangement is acclimated to dry the aeroembolism air on railway locomotives, area abstract and ice in the anchor air pipes can advance to anchor failure.
Silica gel is sometimes acclimated as a canning apparatus to ascendancy about clamminess in building and library exhibitions and storage.
Other applications cover analytic analysis strips, assimilation devices, syringes, biologic analysis kits and hospital sanitation kits.More about: Silica gel sale
Read more: Pyridine synthesis
Wednesday, March 14, 2012
What is Terreic acid?
Description of Terreic acid
Terreic acid is a metabolite that displays antibiotic properties. It has been found to covalently inhibit UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA), a bacterial cell wall biosynthetic enzyme. It has also been found to inhibit the catalytic activity of Bruton’s tyrosine kinase (BTK) and the interaction of BTK with protein kinase C beta type (PKCβII) without affecting the activity of PKC. Terreic acid is useful to study BTK’s role in cellular signaling.
Biological Activity
Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.
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Terreic acid is a metabolite that displays antibiotic properties. It has been found to covalently inhibit UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA), a bacterial cell wall biosynthetic enzyme. It has also been found to inhibit the catalytic activity of Bruton’s tyrosine kinase (BTK) and the interaction of BTK with protein kinase C beta type (PKCβII) without affecting the activity of PKC. Terreic acid is useful to study BTK’s role in cellular signaling.
Biological Activity
Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.
More about: Terreic acid sale
Read more: Probiotics
Tuesday, March 13, 2012
What is Diphenolic acid?
Diphenolic acid is a carboxylic acid with molecular formula C17H18O4. Its IUPAC name is 4,4-bis(p-hydroxyphenyl)pentanoic acid, and it can be prepared by the condensation reaction of phenol with levulinic acid in the presence of hydrochloric acid. The equation for this synthesis is: 2 C6H5OH + CH3C(O)CH2CH2COOH → CH3C(p-C6H4OH)2CH2CH2COOH + H2O
Diphenolic acid is a solid at room temperature, melting at 168–171 °C and boiling at 507 °C. According to its MSDS, diphenolic acid is soluble in ethanol, isopropanol, acetone, acetic acid, and methyl ethyl ketone, but insoluble in benzene, carbon tetrachloride, and xylene.
Diphenolic acid may be a suitable replacement for bisphenol A as a plasticizer
Application
Used to prepare various kinds of synthetic resins, electrophoretic coatings, glossy printing inks and coatings etc.
More about: Diphenolic acid Sale
Read more: Pyridine synthesis
Diphenolic acid is a solid at room temperature, melting at 168–171 °C and boiling at 507 °C. According to its MSDS, diphenolic acid is soluble in ethanol, isopropanol, acetone, acetic acid, and methyl ethyl ketone, but insoluble in benzene, carbon tetrachloride, and xylene.
Diphenolic acid may be a suitable replacement for bisphenol A as a plasticizer
Application
Used to prepare various kinds of synthetic resins, electrophoretic coatings, glossy printing inks and coatings etc.
More about: Diphenolic acid Sale
Read more: Pyridine synthesis
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